Proven Effective for Treatment-Resistant Depression

SPRAVATO® (intranasal esketamine) is an FDA-approved treatment introduced in 2019 for adults with treatment-resistant depression (TRD) and for major depressive disorder with suicidal thoughts or actions. Kansas Mental Health Medicine is a certified treatment center for the administration and monitoring of SPRAVATO® in a safe, supportive clinical setting.

Proven effective for treatment-resistant depression, SPRAVATO® may benefit adults with clinical depression who have had an inadequate response to two or more antidepressants. SPRAVATO® can now be prescribed with or without an oral antidepressant, depending on each patient’s individualized treatment plan.

To learn more about how SPRAVATO® works and whether it may be right for you, visit the official SPRAVATO® website: SPRAVATO® Treatment Information

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Finding Relief For

The SPRAVATO® short-term studies evaluated efficacy results at 4 weeks

SPRAVATO® in combination with an oral antidepressant

In a 4-week clinical study, patients were given either SPRAVATO® in combination with an oral antidepressant or a placebo nasal spray plus an oral antidepressant. The study showed:

  • Rapid and superior reduction in depression symptoms at ~4 weeks for more patients using SPRAVATO® in combination with an oral antidepressant, as compared with patients who received a placebo nasal spray plus an oral antidepressant*
  • Most of the reduction in depression symptoms was seen at 24 hours
  • Continued improvement between 24 hours and ~4 weeks; the difference in improvement between groups did not appear to increase through 4 weeks

SPRAVATO® alone

Patients in the clinical study were randomly placed into one of two treatment groups receiving either SPRAVATO® alone or placebo alone. The study showed:

  • Rapid and superior reduction in depression symptoms at ~4 weeks and 24 hours for patients using SPRAVATO® alone, as compared to patients who received a placebo nasal spray alone*

*Based on an overall score on a standardized rating scale.

SPRAVATO® was also studied in a long-term, maintenance-of-effect trial

SPRAVATO® in combination with an oral antidepressant

SPRAVATO® was studied to see if the effect of treatment was maintained over time. The study showed:

  • Patients who stayed on SPRAVATO® were less likely to experience a return of depressive symptoms (known as relapse) compared to patients who stopped therapy
  • The trial compared patients who stayed on SPRAVATO® with an oral antidepressant to patients on a placebo nasal spray and oral antidepressant, long-term

Expert Monitoring & Compassionate Care

Administering SPRAVATO® requires specialized certification and a high level of clinical expertise. Meet the dedicated medical professionals who will guide you through your treatment protocol, ensuring your utmost comfort, safety, and progress during every in-office session.

Nicole Xanders-Danler

Medical Provider

Satinder Mahal, D.O.

Medical Doctor

Amy Adams

APRN

Tera Price

PMHMP-BC

Natalie St Clair

APRN

Rachel Mohr

PMHNP-BC

Abby Leis

MS, LPC

Tracy Caldwell

APRN-BC

Lisa Bohon

PMHNP-BC

Tabitha Winter

LCPC

Sarah Bahns

LCMFT

Sarah Blosser

APRN, BC

Ericka Purcell

MS, LCMFT

Taylor Courtois

MSN, APRN-C

Kurt Leis

MSN, APRN, BC

Shaina Morgan

APRN, PMHNP-BC

Jessica Moyer

MSN, APRN, PMHNP-BC

Brianna Lee

DNP, FNP-C, APRN

Caleb Ediger

APRN-BC

Cassandra Hinerman

PHMNP-BC

Carly Svoboda

PMHNP-BC

Jennifer Hubbard

MSN, PMHNP-BC

Candra Manley

APRN

Eric McDaniel

LMLP

Trever Krehbiel, MD

Medical Doctor

Falon Nelson

APRN

Tracey Small

MSN, PMHMP-BC

KMHM is a soothing atmosphere, which helps with my treatments. They take such good care of me while I'm there.

KMHM is a soothing atmosphere, which helps with my treatments. They take such good care of me while I'm there.

I thank Jesus Christ for the whole KMHM team!! I was in a very dark and hopeless place when I began the infusions, and after many years of suffering with depression and anxiety, the medical community was at a loss regarding my case, until I was finally directed to KMHM!! I'm LITERALLY on ONE-FOURTH of the dosage of antidepressants I was taking prior to the infusions and I feel a thousand times better! I am finally able to work and I'm starting college again, and that wouldn't have been possible without the knowledge, care and work of the whole KMHM team!! These infusions have definitely been life changing, not only for me, but also for my family who have suffered with me.

I thank Jesus Christ for the whole KMHM team!! I was in a very dark and hopeless place when I began the infusions, and after many years of suffering with depression and anxiety, the medical community was at a loss regarding my case, until I was finally directed to KMHM!! I'm LITERALLY on ONE-FOURTH of the dosage of antidepressants I was taking prior to the infusions and I feel a thousand times better! I am finally able to work and I'm starting college again, and that wouldn't have been possible without the knowledge, care and work of the whole KMHM team!! These infusions have definitely been life changing, not only for me, but also for my family who have suffered with me.

Spravato has been a welcome addition to my depression treatment. I don't know where I would be without it!

Spravato has been a welcome addition to my depression treatment. I don't know where I would be without it!

Before beginning Ketamine infusions for the first time, I was experiencing chronic depression and anxiety for the last 8 years. I had difficulties going to work, getting out of bed, leaving the house, showering, not taking care of myself, not exercising, pushing away everyone who loved me, partying, and I knew this wasn’t the real me. I simply couldn’t find a way out. Then, I came across ketamine infusion therapy, and my life would never be the same again. After the initial six infusions over two weeks I was showing many signs of improvement. Several weeks later things kept improving. Having maintenance infusions every so often since beginning, I can honestly say I genuinely feel like myself again and feel like I am actually LIVING my life rather than just waiting to die. After so many years of frustration and hopelessness, the feeling of the dark cloud over my head going away has been life-changing.

Before beginning Ketamine infusions for the first time, I was experiencing chronic depression and anxiety for the last 8 years. I had difficulties going to work, getting out of bed, leaving the house, showering, not taking care of myself, not exercising, pushing away everyone who loved me, partying, and I knew this wasn’t the real me. I simply couldn’t find a way out. Then, I came across ketamine infusion therapy, and my life would never be the same again. After the initial six infusions over two weeks I was showing many signs of improvement. Several weeks later things kept improving. Having maintenance infusions every so often since beginning, I can honestly say I genuinely feel like myself again and feel like I am actually LIVING my life rather than just waiting to die. After so many years of frustration and hopelessness, the feeling of the dark cloud over my head going away has been life-changing.

KMHM and your team has saved my son's life. I have no doubt.

KMHM and your team has saved my son's life. I have no doubt.

My provider at KMHM has been so helpful in sorting out my medications and helping me resume functioning.

My provider at KMHM has been so helpful in sorting out my medications and helping me resume functioning.

Find Lasting Relief in a Safe Environment.

If two or more antidepressants haven’t adequately worked for you, ask Kansas Mental Health Medicine if SPRAVATO® may be able to help.